DNA Data Storage: What the Experts Aren't Telling You

A few years back, a TED talk featuring scientist Dina Zielinski caught my attention through a seemingly mundane plastic tube.

With a twinkle in her eye, she held it up and proclaimed, “I can fit all movies ever made inside of this tube. If you can’t see it, that’s kind of the point.” What she was referring to wasn’t a magic trick, but a ground-breaking concept: DNA data storage.

DNA data storage is a method of encoding and storing digital information in the sequence of synthetic DNA molecules, leveraging DNA's compactness and durability to hold vast amounts of data in a tiny physical space.

Zielinski’s talk continued, focusing on the DNA’s three famous virtues. One is its density (as mentioned earlier). Two, its durability (potentially lasting millions of years without the need for electricity). Third, DNA’s universality as the code of life ensures continued compatibility with future reading and writing technologies.

Such positive portrayals of the biomolecule in the context of data storage have been reverberating across press releases and social media posts, painting a utopian vision of its application.

DNA-based data storage is emerging as the heralded ‘ultimate solution’ to the challenges stemming from our exponential data generation. It offers infinite storage for indefinite periods.

However, while these prospects of DNA data storage look promising, as with many technological breakthroughs, underneath its promotional veneer might lie an area for scrutiny and critique.

I feel that after several years of almost one-sided promotion of the technology, the public needs to be shown a balanced view rather than an all-out embrace. One area that deserves closer scrutiny is the social and cultural challenges that may arise from archives that are made/encoded with DNA.

Accessibility of DNA-Based Archives

So what kind of data storage would the DNA-based technology allow? The commonly talked about application — at least in the early phase of its rollout — is for archiving. DNA data storage not only consumes high monetary investment, but it also is time-consuming, both to sequence data into DNA and to extract data. For these two reasons, the current recommendation from the experts is to use DNA storage for archival.

But here’s the thing: when it comes to storing data in DNA, there’s a missing piece in the conversation — ensuring these archives stay accessible to everyone, especially for things that are highly valued across societies, such as cultural heritage.

Preserving information isn’t enough; we need an environment where everyone can access and understand this valuable historical data. Making archives accessible means breaking down barriers so that diverse audiences can engage with this wealth of information for research, learning, and safeguarding cultural heritage.

History shows us that accessible archives are crucial to social progress. When archives remain closed or selectively available, communities lose the ability to learn from the past, often repeating preventable mistakes.

For example, restricted access to colonial archives has hindered a full reckoning with colonial histories, affecting reconciliation efforts and justice for communities impacted by past abuses.

Similarly, limited public access to scientific research archives during the early 20th century slowed advancements in public health and technology, widening knowledge gaps.

In contrast, open archives, such as those documenting the civil rights movements, have empowered scholars, activists, and educators to drive social change and ensure past struggles inform future policies.

Accessibility Challenges

Before DNA data storage technology goes mainstream, we have some serious accessibility hurdles to clear. Granted, the technology is still in its infancy. But we should not wait until we have these important conversations. This will give us more time to prepare and expect damaging situations.

DNA is Physical

First up, is about accessing the very archives themselves. Unlike digital data, DNA archives are physical — inconspicuous and invisible, yes, but still tangible molecules. You can’t just click and access them online. It’s not like cracking open your phone; you either have to physically be there to read it or rely on someone else to do the reading for you, which can then be sent digitally.

What’s more, reading and writing require physical machinery to perform them. These archives are often in specific places, which can be a real hassle for researchers or anyone who can’t visit those spots, limiting access big time. Plus, let’s face it, DNA won’t survive a nuclear blast.

To address this challenge, people must engage with gatekeepers, such as companies and governments, to ensure that forthcoming legislation or guidelines account for these accessibility concerns.

One potential approach could involve a hybrid model. Partly digitize archives as a backup. Then, use DNA-based setups for the remainder. This balance would ease digital sharing and accessibility. Companies must consider and explore this avenue if they haven’t already done so.

DNA Technology is Complex

Next, there’s the intellectual side. Understanding how this DNA archiving works isn’t that straightforward. There’s a learning curve to grasp the mechanics of it all, especially since it’s a whole new way of doing things.

There are concerns about the synthetic DNA, the potential confusion from the public who may conflate them with naturally occurring DNA, and data security risks like hacking or corruption, making it hard for people to trust the tech.

Like how some struggle to understand some digital archiving methods (e.g., blockchain), this new DNA system might baffle many.

Further confusion may also arise from the fact that this synthetic DNA can be inserted into living organisms, such as bacteria and plants, which may draw criticism and concern about the ethics of modifying nature and safety issues around data harbouring organisms to go awry with mutations and escape into the wild.

To address this challenge, and to enhance intellectual accessibility, we should improve outreach and educational initiatives. It’s essential to introduce archives to potential users. Also, educate them on effective access and utilization of these valuable resources. This could involve organizing workshops, outreach programs, or creating online tutorials.

DNA Technology is Expensive

Then, we’ve got cost accessibility of the tech. Early on, companies and governments might monopolize the technology. This could lead to potential economic and political divides. Gatekeepers with different motives could control metadata or who can access what. High costs might also lock out those keen on archiving but unable to afford it, creating yet another divide, like the digital gap we’ve seen before.

A proactive strategy to address this issue would be to persuade elitist companies and governments to reduce entry barriers and broaden their customer base, thus enhancing accessibility for all. This involves fostering open-source initiatives, enforcing regulations to prevent monopolies, and allocating public funds to support innovative start-ups.

Additionally, providing accessible education and training programs, encouraging collaborative partnerships, establishing interoperability standards, and engaging communities in decision-making are crucial steps.

In a Nutshell (or a Test Tube)…

The emergence of DNA data storage has brought about vast amounts of enthusiastic portrayal and media’s positive narratives touting the technology as the ultimate solution to manage the overwhelming volume of data humanity generates.

However, this seemingly utopian concept demands scrutiny, especially regarding the accessibility challenges inherent in DNA-based archives. Three distinct types of accessibility challenges loom; physical accessibility of the archives themselves, intellectual comprehension of the technology, and cost.

Physical access involves the inconvenience of accessing tangible DNA archives, limiting widespread access. Intellectual comprehension hurdles arise due to the complexity of the technology, causing potential confusion and security concerns. Furthermore, monopolization, high costs, and technological barriers pose significant challenges to broad access.

Addressing these challenges necessitates proactive measures. Collaborating with technology gatekeepers, advocating for legislative considerations, and promoting hybrid archiving models integrating digital backups alongside DNA storage can enhance physical access. Improved outreach and educational initiatives are crucial for intellectual accessibility.

The DNA Data Storage Alliance (DDSA) exemplifies such collaborative efforts, aiming to educate the public, yet specific strategies remain undisclosed. Encouraging democratization through open-source initiatives, regulatory enforcement, community engagement, and accessible education are vital steps toward broadening accessibility and mitigating the dominance of elitist entities in controlling technological advancements.

Want to Make DNA Data Storage Part of Your Biodesign Practice?

If you’re interested in understanding how DNA data storage could transform your biodesign work and want to learn the principles and workings behind this emerging technology, we can help! Our team is ready to teach you about DNA data storage and how to integrate it. Reach out to us at [email protected] for more information.

And if you've enjoyed this exploration and critique of DNA data storage, check out another article on the same topic here.

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